A recent report described how a mosquito saliva component is required for virus infection.
When infected mosquitoes bite people, they inject viruses and saliva into the skin. The saliva is biologically active and helps the mosquito feed but also helps the virus to infect and replicate.
And ‘host responses to Aedes mosquito saliva is remarkably rapid, inducing peak edema and monocyte influx within minutes postexposure.’
Mosquito Saliva Quickly Spreads Diseases to People
FDA Advisors Back Moderna Shot for Older Children, Teens
Some panel members noted that the vaccine would likely help prevent serious illness but not be as good at blocking mild infections
Disruption to Oncology Clinical Trials Seen Early in Pandemic
Numbers of new patient accruals and newly activated trials decreased early on, followed by progressive recovery