After 40 years, the Bacillus Calmette–Guérin (BCG) vaccine has remained the most effective treatment for non–muscle-invasive bladder cancer (NMIBC), wrote researchers with Memorial Sloan Kettering Cancer Center.
However, tumor recurrence and progression are common, especially for those patients with carcinoma in situ (CIS), commented Eugene J. Pietzak, M.D. and Harry W. Herr, M.D., in an Editorial published by the NEJM Evidence on December 27, 2022.
Furthermore, therapeutic options are limited when BCG treatment fails.
Bladder Cancer Treatment Innovates in the Right Direction
Three-Dose Malaria Vaccine Candidate Shows Promise
A recent article published by the Infectious Disease Special Edition highlights the safety and efficacy demonstrated by Sanaria's non-replicating whole parasite PfSPZ malaria vaccine candidate.
The new study involved 80 participants in a randomized controlled clinical trial comparing three doses of the PfSPZ vaccine against a placebo.
Vaccine efficacy was shown to be 48% at six months (P=0.061) and 46% at 18 months (P=0.018).
Free Spike Antigen ID’d in Post-SARS-CoV-2 mRNA Vaccine Myocarditis
However, mRNA vaccine-induced immune responses did not differ for those who developed myocarditis and those who did not