Parkinson’s Disease (PD) is among one of the common comorbidities in older patients. People with PD may be more vulnerable to severe pneumonia, due to the impairment of pulmonary function. […]
Pregnant and hungry: Addressing food insecurity in pregnant women during the coronavirus disease 2019 (COVID-19) pandemic in the United States.
Food insecurity is a major social determinant of health impacting more than 10% of Americans. Social determinants of health are increasingly recognized as a driving force of health inequities. It […]
Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients.
Standard blood laboratory parameters may have diagnostic potential, if polymerase-chain-reaction (PCR) tests are not available on time. We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be […]
The central role of mitochondrial fitness on antiviral defenses: An advocacy for physical activity during the COVID-19 pandemic.
Mitochondria are central regulators of cellular metabolism, most known for their role in energy production. They can be “enhanced” by physical activity (including exercise), which increases their integrity, efficiency and […]
A comprehensive review of imaging findings in COVID-19 – status in early 2021.
Medical imaging methods are assuming a greater role in the workup of patients with COVID-19, mainly in relation to the primary manifestation of pulmonary disease and the tissue distribution of […]
Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis.
To radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in COVID-19.Between July 1 and August 31, 2020, consecutive patients diagnosed with […]
Extrathoracic manifestations of COVID-19 in adults and presentation of the disease in children.
In March 2020, the World Health Organization declared a global pandemic of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); epidemic conditions continue in nearly all countries […]
Individual and social determinants of SARS-CoV-2 testing and positivity in Ontario, Canada: a population-wide study.
Optimizing the public health response to reduce the burden of COVID-19 necessitates characterizing population-level heterogeneity of risks for the disease. However, heterogeneity in SARS-CoV-2 testing may introduce biased estimates depending […]
Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome.
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive properties. In cancer patients, the expression of lectin-type oxidized LDL receptor 1 (LOX-1) on granulocytic MDSC […]
In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor.
The Coronavirus Disease 2019 (COVID-19) pandemic caused by the novel lineage B betacoroanvirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant mortality, morbidity, and socioeconomic disruptions worldwide. […]