A clinical-stage leader in immune-stimulatory vaccines for cancer announced the publication of its favorable long-term Overall Survival (OS) data from a Phase I trial evaluating a universal cancer vaccine candidate, UV1, in combination with checkpoint inhibitor ipilimumab, in patients with metastatic malignant melanoma.
UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase.
Universal Cancer Vaccine Candidate Presents Positive Long-term Benefits
Tuberculosis Vaccine Recommendations Launch Update Process
The World Health Organization (WHO) announced it is convening a Guideline Development Group to advise on updates to its recommendations on managing tuberculosis (TB) in children and adolescents.
Despite significant progress and greater understanding of the challenges faced in addressing TB in children and adolescents, critical gaps remain in TB case detection and provision of TB preventive treatments, stated the WHO on May 7, 2021.
The first edition of Guidance for national tuberculosis programs on the management of tuberculosis in children was published in 2006.
Suicide mortality data from the Italian police during the COVID-19 pandemic.
Suicide is a major public health issue worldwide, with about 880,000 dying annually for such a cause. The COVID-19 pandemic has led to severe social disruption both from health and […]
Deciphering the role of physical activity in stress management during a global pandemic in older adult populations: a systematic review protocol.
The world has changed dramatically since the beginning of 2020 due to COVID-19. As a result of the pandemic, many older adults are now experiencing an increased and unprecedented amount […]
The Role of Media Sources for COVID-19 Information on Engaging in Recommended Preventive Behaviors among Medicare Beneficiaries Aged ≥ 65 Years.
The public relies on various media sources and communication platforms for receipt of COVID-19 information. Therefore, identifying the primary sources of COVID-19 information among older adults can be valuable, as […]
Immunogenicity of the BNT162b2 mRNA Vaccine in Heart Transplanted Patients-A Prospective Cohort Study.
To assess the short-term immunogenicity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine in a population of heart transplanted (HTx) recipients.A prospective single-center cohort study of HTx recipients […]
Analysis of natural compounds against the activity of SARS-CoV-2 NSP15 protein towards an effective treatment against COVID-19: a theoretical and computational biology approach.
Coronavirus infectious disease 2019 (COVID-19), a viral infection caused by a novel coronavirus (nCoV), continues to emerge as a serious threat to public health. This pandemic caused by SARS-CoV-2 (severe […]
Comparison of infection control strategies to reduce COVID-19 outbreaks in homeless shelters in the United States: a simulation study.
COVID-19 outbreaks have occurred in homeless shelters across the US, highlighting an urgent need to identify the most effective infection control strategy to prevent future outbreaks.We developed a microsimulation model […]
Cytokine Storm in Severe COVID-19 Pneumonia.
In this study, laboratorial parameters of hospitalized covid -19 patients, who were complicated with severe pneumonia, were compared with the findings of cytokine storm developing in macrophage activation syndrome (MAS)/secondary […]
Immune profiling of COVID-19: preliminary findings and implications for the pandemic.
SARS-CoV-2 infection can have widely diverse clinical outcomes, from asymptomatic infection to death, with many possible clinical symptoms and syndromes. It is thus essential to understand how the virus interacts […]